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BRIrnS 785MEDICAL JOURNAL of extrahepatic biliary obstruction, but there were some large soft glands in relation to the common bile duct and the liver was iather pale and its surface granular. A liver biopsy was taken and the abdomen closed. Histological examination showed bile thrombi in the bile canaliculi but no dilatation of the bile ducts, gross perilobular fatty degeneration of the liver cells and slight periportal round cell infiltration but no necrosis of liver cells, no xegeneration, no fibrosis, and no reticulin formation. The laparotomy upset the patient very little, and since operation the jaundice has steadily faded, but a trace is still evident and the liver function tests are still abnormal (see