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ABSTRACT:Aim: We discuss the clinicopathological analysis of cases of chronic vascular rejection (CVR) cases after renal transplantation and clarify the mechanisms underlying the development and prognostic significance of CVR. Loss of the renal allograft occurred during the observation period in nine of the patients (26%). Of the remaining patients with functioning grafts, deterioration of the renal allograft function after the biopsies occurred in 11 patients (32%). Patients: CVR was diagnosed in Conclusion:The results of our study suggest that AMR may underlie CVR in many cases, while T cell-mediated rejection may play an important role in some cases. Chronic vascular rejection (CVR) is a morphologic pattern of chronic kidney allograft injury.1 CVR is vascular changes potentially enable identification of kidneys with chronic/ sclerosing changes due to chronic rejection, described in the Banff 1997 classification.1 While numerous reports have been published on acute vascular rejection (AVR) after kidney transplantation (KTx), which is assigned a 'v' score in the Banff 1997 classification, there are but a few reports on CVR. [2][3][4][5][6] In this report, we present the results of our clinical and pathological analyses of cases of CVR after KTx, and attempt to clarify the underlying mechanisms and prognostic significance of CVR. MATERIALS AND METHODSDuring the period from January 2009 to December 2013, CVR was diagnosed in 46 renal allograft biopsy specimens (BS) obtained from 34 renal transplant patients who were being followed up at the Department of Urology, Tokyo Women's Medical University. The data obtained from the 46 BS and 34 patients were retrospectively reviewed from the clinical records and constituted the subjects of this study. The immunosuppressive protocol mainly consisted of triple-drug therapy with methylprednisolone (MP), cyclosporine (CYA) or tacrolimus (TAC), and mizoribine (MZ), azathioprine (AZ) bs_bs_banner Nephrology 20, Suppl. 2 (2015) 20-25

ABSTRACT:Aim: We carried out a clinicopathological analysis of cases presenting with interstitial fibrosis and tubular atrophy (IF/TA) after renal transplantation in an attempt to clarify the mechanisms underlying the development and prognostic significance of IF/TA.Methods: IF/TA was diagnosed in 35 renal allograft biopsy specimens (BS) obtained from 35 renal transplant recipients under follow up at

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