Internet of Medical Things (IoMT) is the combination of medical devices and utilization by networking technologies. But, the response time and cost were not reduced. In order to address these issues, IoMT Aware Data Collective Quadratic Ensembled Cat Boost Module Classification (IoMT-DCQECBMC) Method is introduced. Initially, IoMT Aware Data Collection is used for gathering data from medical devices. After the data collection process, Quadratic Ensembled Cat Boost Module Classification (QECBM) is carried out in IoMT-DCQECBMC Method to design an efficient VLSI architecture with minimal cost and area. The quadratic classifier is considered the weak learner that categorizes the module for efficient VLSI design. Finally, the weak learners are joined to form the strong classifier to perform non-invasive blood glucose monitoring efficiently. Experimental evaluation is carried out on the factors such as computation cost, area, and accuracy with respect to a number of modules in VLSI circuits. The accuracy of the IoMT-DCQECBMC method is increased by 4% than conventional methods. In addition, the area consumption and computation cost of the proposed IoMT-DCQECBMC method are reduced by 13% to 30% other than existing methods.