The 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate exhibits antiemetic and parasympathomimetic activity. Density () and refractive index (nD) measurements were carried out as a function of drug concentration (c=0.01-0.11 mol·L -1 ) in aqueous NaCl/LiCl (c=0.05, 0.10 and 0.15 mol·L -1 ) solutions at 30 o C. Linear relation of concentration dependence of density and refractive index were studied. Molar refractivity (RM) of solution was calculated from density and refractive index data and polarizability () was calculated from molar refractivity data. Stronger polarizability effects have been observed with increase in drug concentration.

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The paper deals with the calculation of molar refraction ( ) and polarizability ( ) of antibiotic drug ciprofloxacin hydrochloride ( = 0.001-0.029 mol⋅dm −3 ) solutions in ethanol-water mixtures of different compositions (30, 50, and 70% v/v) from measured density ( ) and refractive index ( ) at 30 ∘ C. The effect of drug concentration and composition of ethanol-water mixtures on density and optical properties of drug solutions has been described.

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