A male German shepherd dog of age 2½years was presented at Teaching Veterinary Clinical Complex (TVCC) College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati with a complaint of anorexia, vomiting, pronounced muscle wasting, lethargy and profuse watery diarrhoea. Based on the clinical examinations and haemato-biochemical profile it was diagnosed as Protein losing enteropathy (PLE). The serum albumin concentration was recorded to be 1.7g/dl which is much lower than the normal range. The therapeutic management was rendered with plasma expander, metronidazole, amino acid and multi-vitamin supplement. Prednisolone was administered at tapering dosage in schedule occasions till the animal becomes stable. Feeding of low fat feed along with high protein diet for about 60 days has lead to a remarkable response in gaining body weight.