The authors have carried out an experimental study for the purpose of determining a possibility of differentiating stem cells that are isolated from the adipose tissue according to the adipogenic orientation. The results of the research were indicative of the fact that the cells isolated from the adipose tissue are of specific differentiation, namely, an osteogenic, chondrogenic and, above all, adipogenic orientation that is an evidence of the multipotency of the stem mesenchymal cells of the adipose tissue. The adipose tissue is an alternative source to the bone marrow of multipotent mesenchymal stem cells that can be used as a protection of transplanted autologous adipose tissue from resorption by lipofilling.
The problem of treating patients with no reconstruction of peripheral arterial bed is relevant and it still remans open. The results of the pilot study with a simulated limb ischemia, demonstrated the feasibility and efficacy of fetal liver progenitor cells in activating regenerative and recovery processes as well as angiogenesis.The aim of the research was to investigate the clinical efficacy of cell "indirect" revascularization method in the complrehensive treatment of patients with chronic limb ischemia.The developed method of fetal human liver progenitor cells application in treatment of lower limb ischemia is an effective and affordable method of indirect revascularization. This method is indicated for use in patients whose vascular bed can not be reconstructed, and in elderly patients with severe concomitant pathologies.
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