Introduction The effect of coronavirus disease (COVID-19) on pregnancy outcome in women with sickle cell disease (SCD) is unknown. Objectives To analyze the severity of the SARS-CoV-2 infection in pregnant women with SCD and its impact on pregnancy. Methods This retrospective cohort study included SCD pregnant women tested positive for COVID-19 between March 2020 – February 2021. The primary endpoint was the severity of the COVID-19 infection. Secondary endpoints were pregnancy complications and fetal outcomes. Results During the study period among 82 pregnant women with SCD, 8 have presented symptoms suggestive of COVID-19 and were tested positive. A common mild clinical presentation was observed in 6 women (75%), one woman was asymptomatic and one required oxygen. The latter was admitted to the Intensive Care Unit and a cesarean section was performed in the context of an ongoing vaso-occlusive crisis and acute chest syndrome together with incidental preeclampsia. Labor was induced in another patient who developed a vaso-occlusive crisis after COVID-19 remission. Fetal outcomes were good with an average Apgar score of 10 and normal umbilical blood pH at birth. Two newborns were small-for-gestational-age as expected on the ultrasound follow-up before occurrence of COVID-19. Conclusion COVID-19 infection in our population of pregnant women with SCD had typical presentation and rarely triggered a sickle cell crisis or other complications. Fetal outcomes were good and did not seem to be directly influenced by the SARS-CoV-2 virus. Further studies are required to confirm these observations as compared to the population of women with SCD without COVID-19 infection.

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Ob jec tive: The aim of this study was to eval u ate over weight and obe sity prev a lence and healthy nu tri tion knowl edge in ad o les cents aged 11-14 years, liv ing in the town of Parvomai in dis trict of Plovdiv. Ma te rial and meth ods: The over weight and obe sity prev a lence was as sessed ac cord ing to the in ter na tional cut off points for body mass in dex for over weight and obe sity pro posed by Cole et al, 2000. A ques tion naire of V.Duleva, 2005 was used for eval u a tion of healthy nu tri tion knowl edge. Re sults: The re sults show that 20% of the stud ied boys and 12% of the girls are with over weight and obe sity. The ques tion naire's data show that a con sid er able part of the ad o les cents have not good in for ma tion about healthy nu tri tion. Con clu sion: Rec om men da tions about elab o ra tion of ad e quate ed u ca tional pro grams for nu tri tion in the schools were made. The aim of this strat egy is the de vel op ment of healthy nu tri tional be hav ior in ad o les cents..