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1 Intragastric pressure (IGP) was used as an index, of the effect of serosal application of captopril (SQ 14,225; D-3-mercapto-2-methylpropanoyl-L-proline) on the contractility of rat stomach in vitro. 2 Captopril, at concentrations > 0.3 pm, enhanced the spontaneous gastric motility (GM) in a concentration-dependent manner whereas concentrations <0.3 pM selectively potentiated 4 nm bradykinin (BK)evoked gastric contractions without significantly affecting the spontaneous GM. 3 The kallikrein inhibitor, aprotinin (100uml-1), markedly antagonized the enhanced GM to 1.4pum captopril and BK (4nM)-evoked contractions, without affecting the contractions evoked by angiotensin 1 (10 nM) and acetylcholine (0.4pM). The angiotensin II antagonist, saralasin (50 pM) failed to mimic aprotinin. 4 The enhanced GM to captopril was markedly inhibited by tetrodotoxin (1 pM), and partially inhibited by atropine (1 pM).5 These results indicate that in vitro, captopril (> 0.3 pM) enhances gastric contractility through kininase/ ACE inhibitory action, presumably by increasing the concentration of undegraded tissue kinins and substance P. This motor response seems to be predominantly due to activation of the cholinergic neurones but non-cholinergic excitatory neurones are also involved.

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The seriousness of Covid-19 infection outbreak can be understood by looking at the Govt data or WHO data available. By analyzing the post vaccination experience from medical professionals we can use the data to further motivate general people to take the vaccine and shun the misconceptions and apprehensions related to the presently available vaccines .The objectives of the current study were to collect information about the perception of medical professionals on COVID-19 vaccine, to analyze the side effects in the rst 72 hours of post vaccination period and to associate the side effects with age, gender and presence of apprehensions. By taking the opinion poll and rating of the vaccine experience of medical professionals who are the rst ones on 1 – 10 Likert's scale we can bring out the true picture of their experience which can point towards the efciency of the Government vaccination programme and inspire more people to receive the vaccine in future to help prevent Covid-19 infection .Our study results can also validate the Govt. ofcial data of vaccination experience and satisfaction of people receiving it for the rst time and thereby making this drive a successful one.