Background: It is unknown whether proteinuria caused by ramcirumab (RAM) induces renal dysfunction. Thus, this study assessed the relationship between proteinuria and other factors with RAM therapy, and compared estimated glomerular filtration rate (eGFR) with or without proteinuria in long-term treatment.Methods: Medical records were retrospectively reviewed for 156 patients treated with chemotherapy that included RAM between April 1, 2015 and May 31, 2019 at Kure Medical Center. Forty-eight patients with a performance status of 3 or 4, or not measured for proteinuria among those treated with RAM, or has detected proteinuria before first commencing RAM administration were excluded. Proteinuria and eGFR were measured before treatment with RAM, and compared to minimum eGFR with or without proteinuria after treatment with RAM. The proteinuria group was defined as proteinuria detected at more than 1+ at least once.