Pakistan is blessed with a variety of plants that are being used for multiple purposes and medical uses. The uses of these plants related to their essential properties and proper uses are well known at the community level, while exploration at a medicinal scale is still needed. Anthropogenic activities and rise in population followed by poverty and ignorance, the significant plants are at risk. The comparatively more prosperous cover area of the herbaceous flora has vanished from about 60% of their habitats. The total flora of Pakistan, which is threatened, is more than 15% that includes many endemic species. These plants need to be preserved before they disappear because of excessive commercial harvest and local uses. Various exertions are mandatory for the proper documentation of plants, including recognizing endangered, endemic, and threatened country flora, which collectively forms the Red List. It required training of the local people for the proper conservation of the i) medicinally significant plants, ii) reduce anthropogenic pressure, and iii) Research and development of diverse methods for the conservation of endangered flora.