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In this study, an analytical strategy was proposed for the determination of cobalt at trace levels by using a flame atomic absorption spectrophotometry (FAAS) system after magnetic hydrogel based dispersive solid phase extraction (MH-DSPE).

This study proposed a precise/accurate analytical method for the paracetamol (PCT) determination in human serum/urine matrices. PCT was simultaneously derivatized and preconcentrated by dispersive liquid‐liquid microextraction (DLLME). Benzoyl chloride dissolved in dichloromethane was used as derivatization agent in the extraction solvent. Quadruple isotope dilution (QID) method with three calibration mixtures (A*B‐x, x=1,2,3) and one sample mixture (AB) was performed to enhance the method accuracy and precision. In our research laboratory, paracetamol benzoate‐d3 (PCT benzoate‐d3) was synthesized and used as isotopically labelled substance (B) to conduct QID method. After the combination of QID and DLLME‐GC‐MS systems, percent recovery results for human serum/urine matrices were found to be 99.3–101.0 % and 98.8–99.9 %, respectively.