Purpose: Gabapentin's role in the treatment of chronic neuropathic pain is well known. What is less well established is its role for managing postoperative pain. In order to clarify whether gabapentin's utility in acute pain control is more than just theoretical, we conducted a meta-analysis of all randomized trials that addressed gabapentin's role in acute postoperative pain control. We specifically addressed whether gabapentin reduces pain scores, analgesia consumption, and/or analgesia-related side effects in the first 24 hr following surgery.
Source:We identified eight placebo-controlled, randomized controlled trials and conducted a meta-analysis using the primary outcomes of pain scores, total analgesia consumption, and side effects over a 24-hr period.
Principle findings:Patients who received gabapentin preoperatively reported significantly lower pain scores (-11.9 at rest and -11.0 with movement on a 100-point visual analogue scale) and opioid consumption (-14.7 mg of morphine in 24 hr) with no difference in the incidence of side effects.
Conclusion:Although gabapentin given preoperatively decreases pain scores and analgesic consumption in the first 24 hr after surgery, the clinical significance of this finding has yet to be determined. This meta-analysis could not demonstrate a significant reduction in the incidence of side effects. Due to the small numbers enrolled in the studies, larger randomized control trials are warranted.
Objectif : Le rôle de la gabapentine dans le traitement de la douleur neuropathique chronique est bien connu. Ce qui l'est moins, c'est son rôle dans le traitement de la douleur postopératoire. Pour le vérifier, nous avons fait une méta-analyse de toutes les études randomisées qui ont abordé le rôle de la gabapentine dans le contrôle de la douleur postopératoire aiguë. Nous avons surtout cherché si la gabapentine réduit les scores de douleur, la consommation d'analgésique et/ou les effets secondaires reliés à l'analgésie des 24 premières heures postopératoires.
Source : Nous avons repéré huit études randomisées, contrôlées contre placebo et mené une méta-analyse en utilisant les principaux paramètres des scores de douleur, consommation totale d'analgésique et effets secondaires pendant 24 h.Constatations principales : Les patients qui ont reçu de la gabapentine préopératoire ont présenté des scores de douleur (-11,9 au repos et -11,0
In this randomized trial, we found no differences in nerve visibility, block success rate, or onset between the AC and Peri-SBDGA techniques of ultrasound-guided saphenous nerve blockade, although the former technique provided superior vascular landmark visibility. Neither technique produced a sufficiently high success rate to provide reliable surgical anesthesia per se.
Ultrasound-guided SIJ injection with fluoroscopic confirmation has similar accuracy and efficacy to fluoroscopy alone for SIJ injections in patients with chronic low back pain secondary to SIJ arthritis.
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