Data Fig. 3a-c, Supplementary Table 3). An interactive data browser for the atlases is publicly available (see 'Data availability'). Notably, our bulk RNA-seq and single-cell data were highly concordant, which indicates that our single-cell analytical approach did not introduce technical bias (Extended Data Fig. 3d).

No abstract

Highlights d Beige fat progenitors are marked by cell surface proteins, PDGFRa, Sca1, and CD81 d Beige APC proliferation is regulated by temperature, genetic background, and aging d CD81 mediates integrin-FAK signaling in response to irisin d CD81 loss causes obesity, insulin resistance, and adipose tissue inflammation