• Sulfonylureas effectively reduce hemoglobin A1c by an expected 1.0%-2.0%. Maintaining glycemic control has been shown to lower morbidity secondary to microvascular complications including retinopathy, neuropathy, and nephropathy.• Glyburide is metabolized to active metabolites that may accumulate in patients with renal dysfunction and has been associated with a 2-fold incidence of hypoglycemia in elderly patients compared with glipizide.What is already known about this subject
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.