OPC survivors provide a robust description of their long-term outcomes with 15.5% expressing "moderate to high" regret that was significantly associated with late symptom burden and multimodality treatment. Difficulty swallowing was the strongest driver of decisional regret.

Background To examine swallowing-related lower cranial nerve palsy (LCNP) in oropharyngeal cancer (OPC) survivors after intensity modulated radiotherapy (IMRT). Methods Patients treated with definitive IMRT (66–72 Gy) were pooled from trial databases. Prospective analyses on parent trials included videofluoroscopy, clinical LCNP examination, and questionnaires pre- and 6-, 12-, and 24-months post-IMRT. Time-to-event and incidence of LCNP was estimated with competing risk methods. Literature review (1977–2015) summarized published LCNP outcomes. Results Three of 59 OPC survivors with a minimum 2-year follow-up developed hypoglossal palsy ipsilateral to the index tumor (median latency: 6.7 years, range: 4.6–7.6). At a median of 5.7 years, cumulative incidence of LCNP was 5%. LCNP preceded progressive dysphagia in all cases. Published studies found median incidence of radiation-associated LCNP was 10.5% after NPC, but no OPC-specific estimate. Conclusions While uncommon, the potential for late LCNP preceding swallowing deterioration highlights the importance of long-term functional surveillance in OPC survivorship.

4. Laryngoscope, 128:1044-1051, 2018.

The Home Office's purpose is to build a safe, just and tolerant society in which the rights and responsibilities of individuals, families and communities are properly balanced and the protection and security of the public are maintained. RDS includes staff within the Government Statistical Service (GSS). One of the GSS aims is to inform Parliament and the members of the public about the state of the nation and p rovide a window on the work and perf o rmance of government, allowing the impact of government policies and actions to be assessed. Therefore-Research Development and Statistics in the Home Office improves policy making, decision taking and practice in support of the Home Office purpose and aims, to provide the public and Parliament with information necessary for informed debate and to publish information for future use.

Background: There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading.