Key Points
IL-15 has been implicated in CNS disease and leukemogenesis, but the biological mechanisms are unknown. IL-15 increases pre-B ALL growth and upregulates CNS homing molecules, and MEK/ERK, PI3K, and NF-κB inhibitors block IL-15 growth effects.
Findings offer a thematic framing that may support and deepen practitioners understanding of recipients' emotional reactions during bad news consultations.
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