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Medical Research Council and Leukaemia and Lymphoma Research.

No abstract

Key Points• Integrating cytogenetic and genomic data in pediatric ALL reveals 2 subgroups with different outcomes independent of other risk factors.• A total of 75% of children on UKALL2003 had a good-risk genetic profile, which predicted an EFS and OS of 94% and 97% at 5 years.

Key Points• Infection is the major cause of treatment-related mortality in pediatric acute lymphoblastic leukemia and is greatest during the induction phase.• Children with Down syndrome are at high risk for infectionrelated mortality throughout all treatment phases, including the low-intensity maintenance phase.