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Background: The choice of empirical antibiotic therapy in surgical ICU should be based on antibiotic guidelines to decrease the possible risk of severe infection which may rise the morbidity among the critical patients in the same ICU. Objective: The aim of this study is to create guidelines of antibiotic therapy to decrease the risk of complicated infection in patients in surgical ICU in Aljumhori teaching hospital. Patients and methods:The study was performed between December 2011 and February 2012 in the twelve -beds surgical ICU (SICU) in Al jumhori teaching hospital. Results: The research was done in the intensive care unit in Aljumhori teaching hospital and we found that the result is can be applicable in future to decrease the morbidity and mortality. Conclusion: The main drugs which can be used empirically are chloramphenicol, Azteronam , Amikacin, , Norfloxacin, Erythromycin , Rifampicin, Tetracycline and Trimethoprim.

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