Both therapeutic options are associated with an activation of thrombogenic and fibrinolytic markers within 3 months of use. Tibolone appears to produce a better balance between thrombogenesis and fibrinolysis. Since our results show a lower incidence of thrombotic events, further studies are required.

We conclude that in tgerm neonates with severe perinatal asphyxia oliguric ARF was the predominant type of ARF. There is a good prediction of the severity of oliguric ARF according to the degree of perinatal asphyxia determined by Apgar score at 1 min.

Orthopaedic procedures and anaesthesia are not physiological states. To prevent orthopaedic sequelae, laboratory diagnoses are of proven value in preoperative and postoperative complications as well as preoperative diseases. Laboratory analyses have an important contribution to early diagnosis of infection, haemostasis disorders, electrolyte disbalance, and acid-base disturbance. Laboratory analyses also have a role in monitoring the effect of therapy. Metabolic bone diseases such as osteoporosis affect many patients. Laboratory analyses are useful in evaluating the treatment for preventing fractures. This article discusses specific factors causing postoperative bleeding and thrombosis after orthopaedic surgery.

In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-α and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-α and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-α and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-α values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenasе, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactates

Establishing of hormonal disturbances is one of the most important steps in infertility studies. The aim of the study was to evaluate the importance frequency and treatment efficiency of hyperprolactinaemia in infertile patients. Eighty-seven infertile patients have been examined in this study. Matched samples of periph?eral blood were taken for hormonal analyses in the early follicular, periovulatory and midluteal phases of the cycle. Between the 4th and 7th day of the cycle ultrasonographic and haemodynamic examinations have been carried out at the ovarian and uterine levels. Hyperprolactinaemia was detected in 25 women, in which prolactin levels ranged 628.4-8000 mIU/L. We started dopamine agonists (bromocriptine/cabergoline) treatment individually dosaged. Menstrual cycle as well as prolactin levels restored in all patients 3 months after treatment initiation. Hyperprolactinaemia can derange fertility potential so its early and precise detection and adequate therapy are essential for restoration of regular menstrual cycle and successful infertility treatment.