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We present a case of reconstruction of the philtrum with a unilateral superiorly-based nasolabial island flap following a secondary Millard's bilateral cheiloplasty in a 23-year-old man with cleft lip and palate. His philtrum consisted of a full-thickness skin graft transplanted at one of his previous operations.

The authors make a review of the current literature on the subject of bisphosphonateassociated osteonecrosis of the jaw bones. The modern theories about the occurrence of this complication resulting from bisphosphonate treatment of diseases characterized with high bone resorption are discussed. Modern understandings about the causes, risk factors and triggers for the occurrence of this disease are described. Attention is paid to the modern concepts of medication therapy and surgical treatment. A case of bisphosphonate-associated osteonecrosis of the maxilla with involvement of the maxillary sinus is reported. Surgical intervention comprising sequestrectomy, radical maxillary sinus surgery and plastic closure of the formed oroantral communication is described.

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