Background: Nursing informatics must be integrated into daily nursing practise due to the growing complexity of the healthcare industry and the nursing profession, which will positively affect their attitudes toward information technology. Aim: This study aimed to assess the relationship between nurses' attitudes towards the use of computer and their informatics competencies in nursing practice. Methods: At Beni-Suef University Hospital, all inpatient care units utilized a descriptive, correlational design. The study included a convenient sample of 300 staff nurses from various departments. Researchers used the nurses' computers and information technology questionnaire tool and the nursing informatics competencies questionnaire. Results: Most of the nurses polled had negative attitudes toward nursing informatics, and the overall mean of the informatics competencies of the nurses polled was unsatisfactory. Conclusion: There was a significant positive correlation between the study participants' attitudes towards the use of computer and their overall informatics competencies. Recommendations: Design an appropriate training program to help nurses maintain familiarity with new information technologies, supporting hospitals with resources.