Our results suggest that a 3-fold decreased dose of intravesical BCG is as effective as the standard dose against progression in patients with high risk stages T1G3 and Tis superficial bladder carcinoma but with significantly less toxicity.
RESUMEN
TUMORES DE UROTELIO SUPERIOR OBJETIVOS:Evaluar los métodos diagnósticos empleados, el tratamiento y el seguimiento de los pacientes afectos de tumor de urotelio superior.
PACIENTES Y MÉTODO:Desde 1978 hasta diciembre de 2002 han sido operados 105 pacientes afectos de tumor de urotelio superior, siendo válidos para el análisis 94. La edad media ha sido de 65 años, siendo el 85% varones. La hematuria fue el síntoma más frecuente de presentación.RESULTADOS: Se realizó UIV en el 93% de los pacientes, la ecografía en el 77% y el TAC en el 67%. Predominó el tumor piélico (71%) y el tratamiento mayoritario fue la nefroureterectomía total con resección del collarete vesical perimeatal (76,4%). El tumor vesical previo o simultáneo se constató en 22 casos (23,3%) y posterior en 28 casos (30%). Con un seguimiento medio de 76 meses, la supervivencia es del 53%.CONCLUSIONES: El tumor de urotelio superior debe considerarse como una enfermedad panurotelial debido a la alta frecuencia de tumor vesical previo, simultáneo o posterior, lo cual empeora aún más el pronóstico de esta enfermedad.PALABRAS CLAVES: Tumor urotelio superior. Enfermedad panurotelial. Nefroureterectomía total.
ABSTRACT UPPER URINARY TRACT TUMOURS OBJECTIVE:To evaluate diagnostic techniques, treatment and follow-up in 94 patients affected of upper urinary tract tumor.
PATIENTS AND METHOD:From 1978 to december 2002 we operated 105 patients due to upper urinary tract tumor, although only 94 are valid for analysis. Mean age was 65 years and 85% were man. Haematuria was the most frequent symptom.RESULTS: Urography (93%), ecography (77%) and CT (67%) were the most used diagnostic techniques. Pelvic tumor was the most frequent (71%) and total nephroureterectomy including bladder cuff the chosen treatment (76.4%). Previous or simultaneous bladder tumor was observed in 23% cases and delayed in 30%. With a mean follow-up of 76 months the patient survival is 53%.CONCLUSIONS: Due to the high frequence of previous, simultaneous or delayed bladder tumors, the upper urinary tract tumor should be considered as a panurothelial disease, worsening the outcome of this kind of tumors.KEY WORDS: Upper urinary tract tumor. Panurothelial disease. Total nephroureterectomy.
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