Consensus points in clinical management of GIST as well as questions for future clinical trials were identified during this consensus conference on GIST management.
Deletions affecting codons 557 to 558 are relevant for the prognosis of RFS in GIST patients. This critical genetic alteration should be considered to be a new prognostic stratification variable for randomized trials exploring imatinib mesylate in the adjuvant setting in GIST patients.
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