In this research, the actions of antibiotic trimethoprim alone and with metals combained. Then assayed through formation of base transition metal compounds as ligands have the chance to achieve an unusual arrangement and stability complexes of coordination. We show advancement in using transtional metal compounds medications for treamentt manyl human illnesses such as carcinomas, lymphomas, control of infections, anti-inflammatory disorders, diabetes, with neurological conditions. This combination with transition metal observed the interaction can be separated by derivative spectroscopic method and measure the characterization of compound by IR and UV spectroscopy.

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