COVID-19 is a severe acute respiratory syndrome caused by a novel strain of coronavirus (SARS-CoV-2) and is declared as a global pandemic by WHO as it caused severe damage to mankind by virus transmission from human to human with increased mortality rate worldwide. Corona virus is a spherical shaped and enveloped positive-sense single stranded RnA virus with a size of ~30 kilobase encoding various structural, non-structural proteins and accessory proteins. the entry of coronavirus into the host cells is mediated by spike proteins which efficiently allow SARS-CoV2 to replicate in host cell by evading immune surveillance like innate and adaptive immune responses in the host cells and ultimately leads to increased virulence and disease outcome. In the current review, we highlighted the molecular insights of SARS-CoV-2 and its infection mechanism in the host cell via host-viral protein interactions based on currently available data up to 16 th May 2020 and using various research literature databases. the detection of coronavirus is mainly by Rt-PCR and serological tests. there is no complete treatment for COVID-19, few methods like plasma therapy and remdesivir treatment are reported to show promising results in improving patient's health and decreasing mortality rate.