Background: The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID-19 into a severe and critical stage, underlying comorbidities such as hypertension, diabetes, obesity, chronic lung diseases, heart, liver and kidney diseases. Aims and Methods: This study was designed to investigate Measurement of serum C-reactive protein( CRP) level, plasma D-dimer level and evaluate the levels of each one of the studied parameters between patients infected by coronavirus COVID-19 and no associated comorbidities and patients infected by coronavirus COVID-19 with associated comorbidity (Diabetes , Hypertension). Results: The mean of CRP was 19.31 ± 8.205 in control, , 96.80 ± 18.33 in HTN, 51.08 ± 16.56 in DM group, while mean of  D-dimer was 560.45 ± 155.13 in control group, , 1178.86 ± 379.12 in HTN group, 1529.51 ± 530.20 in DM group of patients.