Background. Arthritis is a common condition that co-exists in the elderly population. This condition leads to frequent administration of comorbid analgesics especially non steroidal anti-inflammatory drugs (NSAIDs). Aim. To study cardiorenal toxicity of celecoxib versus ibuprofen in arthritic patients. Subjects and Methods. Seven hundred ninety-wo arthritic patients were enrolled in the study for 6 months. Three hundred ninety-six patients administered celecoxib 400 mg twice a day; 396 patients administered ibuprofen 300 mg three times a day. Effects measured included investigator-reported hypertension, edema, or congestive heart failure, increases in serum creatinine or reduction in serum creatinine clearance, and changes in serum electrolytes. Results. Celecoxib was associated with significant (P < .05) lower incidence of hypertension and edema in comparison with ibuprofen. Systolic hypertension occurred significantly less (P < .05) with celecoxib compared with ibuprofen. Serum creatinine was significantly increased (P < .05) in patients treated with ibuprofen in comparison with celecoxib. Creatinine clearance was significantly lower (P < .05) in cases treated with ibuprofen in comparison to celecoxib. Nonsignificant changes in serum body electrolytes occurred. Conclusion. The most important finding of this study was the lowering incidence of cardiorenal toxicity of celecoxib in comparison with ibuprofen.

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Breast cancer screening and assessment of symptomatic and newly diagnosed breast cancer patients often encounter axillary adenopathy in diagnostic radiology practise. Axillary adenopathy may be caused by a wide range of disorders. Doctors who are familiar with normal and aberrant nodal morphology and the many causes of adenopathy are more equipped to make an appropriate diagnosis. US is the primary imaging modality for assessing axillary lymph nodes on mammograms, computed tomography (CT), and magnetic resonance imaging. All breast associated axillary masses were studied for their Sonographic and Color Doppler features. Methods: Patients with clinically suspected axillary edoema were enrolled in this investigation, which was conducted in a prospective manner. There was a medical history form completed for each of the participants in this research (Detailed history of the complaint -Results of the clinical examination-Any previous radiological or laboratory examination). The axilla and breast are examined using clinical, ultrasound, and colour Doppler techniques. Further imaging will correlate the results of the ultrasound. Both (Clinical examinations) were used to get the final diagnosis. -MRI. After a biopsy, there is a follow up. Results: Malignant lesions accounted for 35.9% of all related breast lesions, followed by fibroadenosis (25%), and fibrodenoma (9.4%). The most prevalent breast mass was a simple cyst in 3.1 percent of cases, followed by abcess, mastitis, fibrocystic disease, and an accessory breast. Age, marital status, pregnancy and breastfeeding, as well as HTN,DM,SLE, cardiac illness, and bronchial asthma, did not have a significant connection with axillary lesion identified by US, while, HTN,DM,SLE, cardiac disease, and bronchial asthma did. There was a substantial difference in the onset, course, and duration of illness between axillary lesions diagnosed by US. Diagnosis by ultrasound revealed considerable differences in the symptoms of axillary tumours in terms of pain, redness, and heat. US diagnosis of axillary lesions was not significantly different from trauma or discharge. Differences in the location, size, and shape of axillary lesions were found when axillary lesions were analysed by US. While a non-specific lymph node is more likely to be oval or rounded, a suspicious lymph node is more likely to be globular. A considerable discrepancy in the axillary lesions' vascularity and cortical thickness was found between those diagnosed by ultrasound and those by conventional imaging methods based on radiological parameters such as hilum, consistency, and echo pattern. Normal echopattern, solid firmness, normal surrounding parynchyma, and normal cortical thickness were seen in the nonspecific lymph node. Lt and both breasts were found to have soft consistency, form, (smooth, speculated, regular uneven) margins, and substantial ascocation with axillary lesion diagnosis in terms of clinical characteristics. Axillary breast lesions were not related with fibbroglandular lesions in terms of radiologic...

flackground: AjlMo.rins(AF) (Ire co111monly environmental toxicnnt in devc/opitJg tropical cottntnes. •Aim of the work: This study set out to im•estigntc tire prevalence of aflato.xins ottd their metabolites in sera of jaundiced neonates and !heir mother's sem aiUI breast milk using Thin Layer Clrroma rograpl!y (TLC). Srtbjects and methods: Samples were obtai11ed from 200 jaundiced neonates and their mothers, and 60 non jaundiced controls and their mothers ndmirred ro Oenfta universiry ltu! pital, locmed in Qual• yobin gm•emorale, Egypt. Results: AF fe1•els in cases were flisMy signiflcam (Pe corre[(ltiatl (P