HighlightsWe report a rare case of aggressive fibroma at posterior compartment of the knee.The tumor was resected from the posterior compartment with the preservation of neurovascular structures around the tumor.The popliteal space is covered with the heads of gastrocnemius sutured to the hamstring muscles.One year postoperative, the vascularization was good, no recurrence and neurological deficit with MSTS 80%.

SUMMARY:The objective of this study was to design custom-made prosthesis in a certain population, the morphometry needs to be measured. The results of this study were expected to provide basic data to design the ideal size of the total knee arthoplasty prosthesis for Indonesian population. This was an anthropometric study conducted on 100 healthy Indonesian population based on Computer Tomographic (CT) imaging on the distal femur resected surface. The parameters being used were Femoral Medio Lateral (fML) length, Femoral Antero Posterior (fAP) length, Femoral Medial Antero Posterior (fMAP) length, Femoral Lateral Antero Posterior (fLAP) length, and Femoral Aspect Ratio (FR). We found that the mean fAP and fML were 54.60±5.71 and 65.98±6.51, respectively. The morphometry of the distal femur were significantly different between male and female (male have larger build), however one of parameters showed different result: fLAP. This study showed that Indonesian people have smaller build compared with their Western counterpart. The proposed dimensions can be used as the basic data to design the ideal size of the custom-made knee arthoplasty prosthesis for Indonesian population.

Reprocessing of single-use devices is an upcoming issue in the Western world, but has been for many years in developing countries. In developing countries, the number of bone fractures due to traffic or industrial accidents is high. Patients often need an osteosynthesis with plates and screws, but most patients, however, cannot afford this because of the costs involved and have to rely on the application of used plates and screws. This study aims to determine whether used plates can be safely reused in another patient from a biomechanical, surface physico-chemical, and biological point-of-view. Osteosynthesis plates weakened in a predictable way during use, regardless of the history, presumably because tests were conducted under extreme conditions in the absence of clinically applied load-sharing between bone and plate. Surface physico-chemical analyses indicated that used plates and screws were more hydrophilic than new ones; had increased amounts of calcium-phosphates at their surfaces; and possessed higher number of scratches. Pitting corrosion could be seen on SEM micrographs. Simple cleaning methods, as available in developing countries, including toothbrush, water, detergent and bleach yielded elemental surface compositions, and hydrophobicities similar to those of new ones, while biologically thus cleaned screws were not cytotoxic according to ISO-10993-5 and endotoxin release according to USP-27-NF-22 was within the requirements of the FDA. It is concluded that the reuse of osteosynthesis plates and screws is not necessarily unsafe, although preferably a register should be kept of all previous users to limit the number of reuses as mechanical weakening does occur.

A de novo 3‐bp deletion (179–181delGTG) was identified at exon 3 of the PTPN11 gene in a female infant with severe Noonan phenotype including hydrops fetalis and juvenile myelomonocytic leukemia. Since the 3‐bp deletion is predicted to result in loss of the 60th glycine in the N‐SH2 domain that is directly involved in the intramolecular interaction between the N‐SH2 and the PTP domains of the PTPN11 protein, this mutation would disrupt the N‐SH2/PTP binding in the absence of a phosphopeptide, leading to an excessive phosphatase activity. The results expand the spectrum of PTPN11 mutations in Noonan syndrome (NS), and suggest that a PTPN11 mutation leads to a wide range of clinical features of Noonan syndrome. © 2004 Wiley‐Liss, Inc.

The incidence of Deep Vein Thrombosis (DVT) is high in orthopaedic cases, associated with morbidity and mortality. This study was done to evaluate the incidence of DVT and factors that contributed to DVT in elderly patients with proximal femur fracture who underwent surgery. Patients 60 years of age and older with proximal femur fracture who underwent surgery were enrolled into this study. Daily observation of the clinical signs of DVT was done post operatively until the subjects were discharged from the hospital. D-Dimer test and contrast venography were carried out on Day 2 and between Days 4 and 7 after surgery. Results were interpreted as normal and obstruction. There were 42 eligible patients, 18 of them (42.86 %) were diagnosed with DVT. We found that positive D-Dimer test (1.40), longer duration of surgery (1.86), and presence of clinical symptoms (1.09) increased the risk of the occurence of thrombosis although not statistically significant. There were four DVT patients who passed away within 4 months after surgery due to complication from DVT. The incidence of DVT in elderly with proximal femur fracture underwent surgery was relatively high (42.86 %) with the mortality rate was 22%.