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A series of 1-(3,4-dihydro-3-oxo-2H-1,4-benzoxazine-2-carbonyl)-3-methyl-4-(substituted phenylhydrazono)-2-pyrazolin-5-ones have been synthesized by the reaction of 2H-3,4-dihydro-3-oxo-1,4-benzoxazine-2-carboxylic acid hydrazide with substituted acetoacetic ester derivatives using acetic acid as solvent under microwave irradiation (MWI), as well as by conventional methods. The reaction rate is enhanced tremendously and the yields are improved under MWI as compared to conventional methods.

Ultrasound and Microwave Assisted Rapid and Sustainable Route to Synthesis of Benzothiazine Derivatives. -A variety of new benzothiazine derivatives is synthesized by ultrasound and microwave reactions of hydrazide (V) with 1,3-diketo compounds containing active methylene groups. The new compounds show convincing activities against Gram-positive bacteria. -(DABHOLKAR*, V. V.; GAVANDE, R. P.; Indian J.