Background Vitiligo is an acquired depigmenting skin disease which is often accompanied by mental distress. There are numerous studies dedicated to local and global prevalence of depression in patients with vitiligo but anxiety has not been recognized as a major mental problem within named population. We aimed to evaluate the prevalence of anxiety among patients with vitiligo from different countries and to compare it with patients suffering from eczema, psoriasis, and acne. Methods In November 2019, we conducted a systematic search for observational studies that examined the prevalence of anxiety in vitiligo patients. Fifteen studies comprising 1176 patients with vitiligo were included to our systematic review. Results The general prevalence of anxiety among vitiligo patients was equal to 35.8%. Statistically significant difference in anxiety rates was found among female and male patients (47.32% vs 42.4%) (P = 0.03), but the clinical relevance of this issue remains arguable. In addition, the pooled odds ratio among vitiligo and non-vitiligo patients did not indicate a statistical significance among patients coming from different continents. Conclusions The pooled prevalence of anxiety among vitiligo patients worldwide was comparable to other severe skin disorders. This finding accentuates the necessity of anxiety awareness in management of patients with skin diseases.

Vitiligo is clinically characterized by the appearance of non-symptomatic depigmented macules, but the disorder is highly correlated with a wide range of psychiatric disorders and psychological problems. The aim of our study was to investigate serum brain-derived neurotrophic factor (BDNF) and corticotropin releasing hormone (CRH) levels in vitiligo patients and healthy controls in relation to the observed symptoms of depression and anxiety disorders. This study comprised 96 vitiligo patients and 96 healthy controls who filled out the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scales. Serum levels of BDNF and CRH were measured using enzyme-linked immunosorbent assay (ELISA) technique. There was a significant increase of depression and anxiety scores in vitiligo patients as compared with healthy controls (P < 0.05). The serum levels of BDNF were significantly lower in vitiligo patients than in healthy individuals (Z = 4.002; P < 0.001), while the serum levels of CRH were markedly higher in cases than those in controls (Z = 3.764; P < 0.001). The significant positive correlations between serum CRH levels and GAD-7, PHQ-9 scores were observed. However, the aforementioned psychometric scales did not correlate significantly with serum BDNF level. Vitiligo is associated with the depression and is closely linked with lower BDNF levels.

The aim of this research is to determine the characteristics of endothelial factors and the hemostatic system conditions with malignant neoplasms patients, which were exposed to ionizing radiation. Total number of examined people is 223, 153 of them are patients with gastrointestinal tract oncopathology. The article presents the results of the analysis of numerical indicators of endothelial condition and platelet hemostasis of patients, who had cancer. They lived in the regions of Kazakhstan, subjected to contamination of radionuclides as a result of nuclear weapons tests, which took place in this region from 1949 to 1989. These results then were compared to cancer patients and healthy individuals with no radiation risk. The study revealed the presence of higher levels of endothelial dysfunction and following trigger of the hemostatic system in patients with malignant tumors of the gastrointestinal tract. In particular, the defined high degree of endothelial dysfunction include endotheliumdependent vasodilation, content desquamated endothelial cells in peripheral blood and von Willebrand factor. These indicators have a clear correlation with the degree of disorder of studied parameters of the hemostasis, which can cause the development of thrombotic complications.

The purpose of the study was to determine the structure, compliance to antihypertensive pharmacotherapy in patients with arterial hypertension of the third degree in the conditions of Semey and the frequency of achieving target BP.The study included 618 patients with hypertension III degree. The age of patients ranged from 38 to 77 years (mean age -61,2 ± 2,7 years). Among the surveyed men was -353, women -265.Carried out an analysis of medical records and patient survey to determine the structure of antihypertensive therapy, compliance to it and the existing violations preparations reception mode.Was revealed prevalence in the appointment's structure the combinations of antihypertensive drugs (46.0%) and fixed combinations (29.0%). Monotherapy performed more frequently with beta-blockers and calcium channel antagonists.It revealed the greatest compliance to the use of fixed combinations of drugs and most high clinical efficacy of antihypertensive therapy options.Keywords: arterial hypertension -pharmacotherapy -compliance. ТҰЖЫРЫМДАМАЗерттеудің мақсаты -Семей өңіріндегі артериялық гипертензия ІІІ дәрежелі бар науқастарда, антигипертензивті дәрілік терапияның құрылымын, бейілділігін анықтау мақсатты қан қысымын жетуге жиілігі.Зерттеу үшінартериялық гипертензия ІІІ дәрежесімен 618 науқасенгізілген. Науқастардың жасы 38-ден 77 жылға дейін ауытқиды (-61,2 ± 2,7 жыл орташа жасы). Зерттелгендердің арасында ерлер -353, әйелдер -265 болды.Антигипертензивті терапияның және препараттар құрылымын анықтауы, бейілділігі, препараттар қабылдау режимінің бұзылуын тал-дау үшін, медициналық жазбалар мен пациенттердің зерттеуі өткізілді.Тағайындау құрылымында антигипертензивті препараттарының комбинациялары (46,0%) және тіркелген комбинациялар (29,0%) анықталған. Монотерапия неғұрлым бета-блокаторлармен және кальций арналарының антагонистерімен асырылды.Ең жоғары бейілділігі тұрақты дәрілік комбинацияларды қолданған кезде және ең жоғары клиникалық тиімділігі осы топта анықталған. Маңызды сөздер: артериялық гипертензия -фармакотерапия -бейілділігі.

To determine frequency, structure of antihyperholesterinemic therapy in the east region of Kazakhstan and compliance of the patients.Material and Methods: The pharmacoepidemiological analysis was carried out on the basis of archival documents (medical history, outpatient cards) of 14 treatment and prevention institutions in Semey city of the East Kazakhstan region. A total of 3458 units of primary material were analyzed. The study included medical documentation of people with the diagnosis of ischemic heart disease, arterial hypertension, arterial atherosclerosis of lower limbs and other chronic diseases, as well as clinically healthy individuals with a study of the content of cholesterol in the blood. To determine adherence, the Moriski-Green test is used.Results: It was revealed that the frequency of prescribing antihypercholesterolemic drugs (statins) in the conditions of Semey city is 80.7% of cases from the number of persons with clinical indications for their use. Atorvastatin (89.7%) prevailed in the structure of antihypercholesterolemic therapy in patients with hypercholesterolemia and clinically manifested atherosclerosis. A low adherence to statin therapy has been revealed, reaching only 46.6% of the number of appointments and decreasing to 39.9% in individuals without clinical manifestations of atherosclerosis. The overall frequency of regular statin use in the group average, taking into account prescriptions and adherence, is 37.6% of the number of people with clinical indications and depends on the clinical diagnosis. Conclusion:It is necessary to implement measures to correct the approaches of doctors to the appointment of antihypercholesterolemic therapy and work with patients aimed at increasing adherence to treatment.