a b s t r a c t N-Carboxybutyl chitosan (CBC), collagen/cellulose (Promogran ® ) and hyaluronic acid-based (Hyalofill ® ) polymeric matrices/dressings were loaded with an extract obtained from jucá (Libidibia ferrea) and in order to develop wound dressings endowed with anti-inflammatory activity. Jucá fruits were subjected to supercritical fluid extraction (SFE) using CO 2 at 25 MPa and 50• C and the resulting extract was later incorporated into the above referred wound dressings by a supercritical fluid impregnation/deposition method (SSI). GC analysis revealed that the obtained SFE extract is particularly rich in unsaturated (52%) and saturated (26%) fatty acids as well as in terpenoids (13%) such as lupenone and gamma-sitosterol. Extract loading yields depended on the affinity of the hydrophobic extract for the specifically employed wound dressing material and was almost 2-fold greater for CBC than for the other two commercial wound dressings. The prepared extract-loaded dressings were cytocompatible with RAW 264.7 macrophages (viability > 85% at 24 h) and down-regulated the expression of TNF-␣ and IL-1␣ proinflammatory cytokines as well as the production of nitric oxide, which confirms the anti-inflammatory capacity of the employed jucá extract. Nevertheless, such effect was somehow counteracted by a proinflammatory activity that was exhibited by CBC. Prepared dressings presented a wide range of water vapor ((2.9-14.7) × 10 14 kg/(s m Pa)) and oxygen permeability (150 up to 830 barrer) which make them potentially suitable for the management of various wound types at different healing stages.

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The results support the traditional use of andiroba oil as antiplasmodial, which additionally proved not to be toxic in bioassays conducted with mice.

Objetivos: Traçar o perfil epidemiológico da Hipertensão Arterial Sistêmica em uma população de zona urbana.  Métodos: Estudo descritivo, transversal, com abordagem quantitativa, desenvolvido nas unidades básicas de saúde (UBS) da zona urbana do município de Aldeias Altas-MA. A amostra foi composta por 228 hipertensos cadastrados no programa Hiperdia e acompanhados pela Estratégia Saúde da Família Resultados: O perfil predominantemente encontrado no estudo revelou indivíduos hipertensos do sexo feminino, raça/cor negra, casados, analfabetos, lavradores, com renda mensal de até um salário mínimo, sedentários, não etilistas e não tabagistas, com sobrepeso. Com relação ao estágio da HAS, a maioria encontrava-se com hipertensão leve. Diagnóstico desta patologia há mais de 10 anos, e estes têm hábito de consultar-se uma vez por mês com médico. Antecedentes familiares com hipertensão. A doença associada que apresentou destaque foi DM. E como forma de tratamento da HAS, a maioria realizava dieta (controle do sal) e uso de medicamentos (IECA), mas que não apresentavam aderência ao tratamento. Conclusão: Notou-se que é necessário prestar assistência diferenciada no âmbito da atenção primária, a fim de reduzir a prevalência da hipertensão, no intuito de modificar o estilo de vida e/ou possíveis fatores de riscos e, consequentemente, diminuir a morbimortalidade ocasionada por complicações da HAS.

Objective: To analyze the epidemiological profile of gestational and congenital syphilis in the state of Piauí in the period from 2017 to 2020. Method: This study is a systematic review, based on data in the virtual health library-bvs and PEDro database, using the descriptors: syphilis; gestation; Piauí; epidemiology. The search in the database took place between March and April 2020. Results: In the virtual health library (bvs) database, a total of 45 articles were found on the topic addressed and in the PEDro database, 15 were found. Of these articles, only 07 were selected because they met the inclusion and exclusion criteria. Conclusion: Thus, Piauí needs an improvement in its epidemiological surveillance in order to obtain a reduction in the incidence and mortality rates due to congenital syphilis. It is emphasized that such preventive practices and assistance must involve the entire multidisciplinary health team.