Summary. Hanford miniature pigs have been used as experimental animals in our laboratory for 5 years. Main object of the operative procedures, developped during this time, was the chronic implantation of catheters for injection and infusion or withdrawal of body fluids (blood, gastric juice, urine) without stress in unaesthetized animals. Thus a method for simultaneous catheterisation of a mesenterie vein and vena portae is described which allows besides the already mentioned possibilities the measuring of portal venous pressure and portal blood flow. Physiological data observed in these animals are reported.Key words: Miniature Pig --Housing --Catheter Implantations --Physiological Data.Zusammen/assung. Es wird fiber Erfahrungen berichtet, die in 5 Jahren an Hanford-Miniaturschweinen gesummelt wurden. Den Schwerpunkt der besehriebenen opcrativen Techniken bilden chronische Katheterimplantationen zur streBfreien Injektion oder Infusion und Materialentnahme (Blut, Magensaft, Urin) am wachen Tier. Unter anderem wird eine Methode zur simultanen Katheterisierung einer Mesenterialvene und der Pfortader beschrieben, die neben den oben erwiihnten MSglichkeiten Pfortaderdruck-und Pfortaderflowmessungen erlaubt. Daneben werden physiologisehe GrSgen, die an einer gr6geren Zahl yon Hanford-Miniaturschweinen gewonnen wurden, mitgeteilt.Schli~sselw6rter: Miniaturschwein --Haltung --Katheterimplantationen --Physiologische Normalwerte.Das Sehwein gewinnt als Versuehstier zunehmende Bedeu~ung in der experimentellen Medizin, da es sieh dureh die weitgehende ~bereinstim-mung seiner biologischen Daten mit denen des Mensehen fiir eine Vielfalt yon Untersuchungen besonders eignet. Diese 13bereinstimmung betrifft insbesondere Fettstoffwechsel, I-Ierz und Kreislaufsystem inklusive

Congenital malformations of the inner ear are well described, though the combination with cerebrospinal fluid (CSF) leaks remains controversial. In this paper a case of a bilateral Mondini malformation with a CSF otorrhea on one side is reported. The malformed stapes contains a perforation in the middle of the footplate and associated thinning analogous to a pothole in a mountain stream. The histological findings support the hypothesis of pulsatile flow of CSF as origin of the perforation of the footplate.

Binaural hearing is essential for localization abilities and improves the speech perception in noise. Since 20 years, bilateral cochlear implantation is routinely performed to restore binaural hearing. In this cross-sectional study, we evaluated speech perception in quiet (Freiburger monosyllables, Hochmair-Schulz-Moser (HSM) sentence test, each at 70 dB) and in noise (HSM test, signal-to-noise ratio 10 dB) in 103 out of 165 adult patients who were bilaterally implanted in Würzburg between 1995 and June 2014. In almost half the patients, the second implanted side showed the better speech perception. Compared to the first implanted side, the average monosyllable scores with bilateral implants were improved from 54 to 63% and the HSM scores from 86 to 96%. In noise the speech perception improved from 47 to 65%. The speech perception of the second implanted side was independent of the time interval between the implantation of both sides in this cohort of postlingually deafened patients. This cross-sectional data underline the importance of bilateral cochlear implantation for speech understanding in quiet and even more in noise and thus, for the everyday life. For this, bilateral cochlear implantation should be the generally accepted standard in the treatment of deaf patients.

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This is the first study about the aetiology of traumatic tympanic membrane perforations in Germany. There is no statistic difference between the 2 materials for tympanic membrane splinting. A traumatic tympanic membrane perforation should be treatet at least to improve the air conduction threshold.