Cancer can conquer or feast on nearly all portions of the body. The cumulative illness and high humanity of cancer generate an innumerable claims for the expansion of innovative anticancer drugs. Coumarin (known as 1,2-benzopyrone or o-hydroxycinnamic acid-8-lactone) encompasses a huge class of phenolic offshoots that originate in plants and they are entailed of bonded benzene and a-pyrone rings. Numerous studies have exposed that several substituents on the coumarin essential structure stimulus different biological activities. Coumarin advert a character of pathways in cancer like kinase inhibition, cell cycle annexation, angiogenesis inhibition, telomerase inhibition, antimitotic activity, carbonic anhydrase inhibition, monocarboxylate transporters inhibition, aromatase inhibition, and sulfatase inhibition. Coumarin moiety is a beneficial template for the progress of novel anticancer agents.

Coumarins and chalcones have been molecules of considerable interest amongst medicinal chemists owing to their vivid pharmacological potentials including anticancer. A few coumarin-chalcone conjugates (C1-C5) with good antioxidant potential were evaluated for in vitro cytotoxicity against A549 cell lines using MTT assay. The IC50 of the conjugates was calculated after 24 h of treatment. The compounds C3 and C4 with higher mesomeric effects exhibited by the substituents were found to be possessing significant cytotoxic potential with IC50 values of 22.90 ± 2.1, 26.73 ± 6.6 µM respectively.