and infantile diarrhea as well as traditional medicine for long days [7]. Leaves are used for treating wounds infected with worms [8]. Locally in Tamilnadu (Tirunelvelli Dist) it is used as anti-diabetic. The present investigation was therefore carried out to study anti hyperglycemic activity of Elytraria acaulis Lind. on streptozotocin-induced diabetic rats Materials and Methods Animals Wistar strains of albino rats of either sex weighing 150-200 g were used as the experimental models. The animals were kept in well ventilated cages and were fed with the commercial pelleted rat chow and water ad-libitum. Animals were maintained in standard animal house. Preparation of plant extract The whole shrub of Elytraria acaulis Lind. were dried and powdered in a mechanical grinder. The powdered material was extracted with methanol using soxhlet apparatus. This extract was filtered and concentrated in vacuum evaporator and kept in vacuum desiccators for complete removal of solvent. The yield was 150 g with respect to 2 Kg of dried powder and used for oral administration.