A series of 2-N-ethoxyphthalimido 3-(4-substitutedphenyl)-6,6-diphenyl-3,3a-dihydro-2H-imidazo[2,1-b] pyrazolo[3,4-d][1,3]thiazol-7(6H)-one(7a-e) and 4-(4-substituted phenyl)-2-(N-ethoxyphthalimido amino)-7,7-diphenylimidazo[2 0 ,1 0 :2,3][1,3]thiazolo[4,5-d] pyrimidin-8(7H)-one (9a-e) have been designed and synthesized starting from thiohydentoin (1). The structure of all synthesized compounds has been established by IR, 1 H NMR, 13 C NMR and mass studies. These compounds have been screened for antimicrobial activities in order to evaluate the possibility of the derivatives to be used as potential chemotherapeutic agents.

Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This chapter summarizes the recent advances in the investigations of synthesis and biological activities of quinazoline derivatives. According to the main method the authors adopted in their research design, those synthetic methods include microwave-assisted reaction, ultrasound-promoted reaction, metal-mediated reaction, water reaction, and phase-transfer catalysis reaction. The biological activities of the synthesized quinazoline derivatives are also discussed.

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