The present study is designed to verify the changes of resistin, malondialdehyde (MDA), glucose and lipid profile in type2 diabetes mellitus.   This study was carried out during the period from November 2013 till January 2014, on 96 subjects: 57 diabetic patients (11 males and 46 females, aged between 33 and 60 years, with a mean age of 40.32) and 39 healthy controls (24 males and 15 females, aged between 40 and 59 years, with a mean age of 47.43), who attended :outpatient, Health care center, and Emergency Department in Tikrit Teaching Hospital. The results showed a significant increase in the salivary glucose, total cholesterol (TC), triglycerides (TG) resistin, and MDA level in diabetic patients compared to controls, while significant decrease in salivary HDL in diabetic patients compared to controls.