Syphilis is one of the oldest diseases known to humans. Its history is as old as history of humans. Syphilis affects sexually active people 15-65 years. Society has laid golden rules for humans. When they get sexually matured family members arrange marriage they can have sexual satisfaction and also can continue their progeny. Society expects them to follow ldquoMonogamy and Monoandryrdquo.If humans ignore the golden rule of monogamy and monoandry and indulge in indiscriminate sexual activity they suffer from sexually transmitted diseases STDs. Syphilis has been the commonest STDs troubling humans since ages. On literature search regarding its origin it can be said that history of syphilis is mysterious. Three important theories explain the origin of syphilis and they are- 1 Columbus theory 2 Hudson theory and 3 European universal theory