Leukodystrophy cases are not common in routine clinical practice. Among leukodystrophies adrenoleukodystrophy (ALD) cases are more common. It presents with neurologic and endocrine features with characteristic Megnetic Resonance Image (MRI) findings and biochemical changes. Early recognition of index case is important because dietary modification & supplementation with Lorenzo’s oil can slow progression of the disease course and can be life saving. Bone Marrow Transplantation (BMT) if performed in earlier stage of disease can be very rewarding to show stabilization and in some instances improvement of patient’s condition. More over prenatal diagnosis of affected boys can be performed by analyzing pedigree chart of an affected family members of this X-linked chromosomal disease. JCMCTA 2016 ; 27 (1) : 68 - 71

Background: PPH is a single largest and leading cause of maternal mortality & severe morbidity in developing countries. A drug is needed which should be effective, cheap, safe, does not need refrigeration and that can be easily administered by untrained person. Misoprostol is the drug that fulfills these requirements. So this study is designed to evaluate the efficacy of Misoprostol in prophylaxis & management of PPH. Materials and methods: This observational study was carried out in the department of Obstetrics and Gynecology of Bangabandhu Memorial Hospital, Chattogram, during the period January to June, 2013. Total 168 pregnant women who were at term and expected to have a vaginal delivery were taken for this study. Results: The median length of the 3rd stage of labour was 8.8 minutes. 11 women (6.54%) required a manual removal of the placenta and 23 patients (13.69%) needed further therapeutic oxytocin to control bleeding. In 145 cases (86.30%) additional oxytocic was not required, about 93.45% cases placenta was expelled out easily by active management of 3rd stage. There was a drop in Hb and haematocrit concentration after delivery, which was statistically significant. An upward trend was (>0.11°F) noticed regarding temperature after delivery. Conclusion: Misoprostol is effective for prevention and management of postpartum haemorrhage, & can consider as a good alternative to other conventional oxytocic drugs. JCMCTA 2019 ; 30 (1) : 47-50

Background: The leading cause of perinatal morbidity and mortality is prematurity in developed and underdeveloped countries. In one third of the patients with preterm labour, there is associated premature rupture of membranes. The study was conducted to evaluate the clinical presentation of Pre-labour Rupture of Membrane (PROM) in pregnancy and obstetric outcome. Materials and methods: This is a cross sectional study carried out in the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, between September 2013 to February 2014. About 50 women having PROM with more than 32 weeks gestational age who admitted in the above department for delivery were enrolled in this study. Results: The mean age was found 27.4 ± 4.42 years with range from 17 to 41 years. Forty eight percent of PROM patient were primi and 52.0 percent of patients were multigravida. Six percent patients were illiterate. Almost two third patients were housewives. More than half (54.0%) of the patients were came from poor class income group family. Majority (64.0%) patients had term PROM (>37 weeks) gestational age and the mean gestational age was 38.1 ± 2.7 weeks with range from 32- 40 weeks. More than half (54.0%) didn't received any antenatal checkup. A total of (56.0%) patients had associated disease, out of which anaemia was more common. Twelve percent had diabetes mellitus and 8.0% had UTI infection. Almost two third (64.0%) was vaginal delivery and 18(36.0%) were caesarean section and common indication for caesarean section was fetal distress (38.9%). Two third patients were healthy and 17 patients had morbidities, wound infection is highest (29.4%). The mean birth weight was found 2.74 ± 0.7 kg. APGAR score >7 at 1 minute was found (92.0%) and (94.0%) at 5 minutes of birth of baby after birth. Fetal outcome take home alive (98.0%) and neonatal death 2.0%. Among 50 foetus morbidity develop in 26 cases. Among them respiratory insufficiency is highest (38.5%). Conclusion: Motivation of the patients, health education, improvement of nutritional status of mother, neonatal care service, early diagnosis, treatment, overall institutional delivery is needed for reduction of neonatal morbidity and mortality, as well as maternal morbidity. Chatt Maa Shi Hosp Med Coll J; Vol.19 (2); July 2020; Page 23-27