Nanocrystalline titanium dioxide (nano-TiO(2)) is an important material used in commerce today. When designed appropriately it can generate reactive species (RS) quite efficiently, particularly under ultraviolet (UV) illumination; this feature is exploited in applications ranging from self-cleaning glass to low-cost solar cells. In this study, we characterize the toxicity of this important class of nanomaterials under ambient (e.g., no significant light illumination) conditions in cell culture. Only at relatively high concentrations (100 microg/ml) of nanoscale titania did we observe cytotoxicity and inflammation; these cellular responses exhibited classic dose-response behavior, and the effects increased with time of exposure. The extent to which nanoscale titania affected cellular behavior was not dependent on sample surface area in this study; smaller nanoparticlulate materials had effects comparable to larger nanoparticle materials. What did correlate strongly to cytotoxicity, however, was the phase composition of the nanoscale titania. Anatase TiO(2), for example, was 100 times more toxic than an equivalent sample of rutile TiO(2). The most cytotoxic nanoparticle samples were also the most effective at generating reactive oxygen species; ex vivo RS species generation under UV illumination correlated well with the observed biological response. These data suggest that nano-TiO(2) samples optimized for RS production in photocatalysis are also more likely to generate damaging RS species in cell culture. The result highlights the important role that ex vivo measures of RS production can play in developing screens for cytotoxicity.

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The adsorption and desorption of Cd(2+) to large and nanometer-scale anatase crystals have been studied to determine the relationship between heavy metal adsorption properties and anatase particle size. A solvothermal method was used to synthesize very fine anatase nanocrystals with average grain sizes ranging from 8 to 20 nm. On a surface area basis, it was found that large and nanometer-scale anatase particles had similar maximum Cd(2+) adsorption capacities, while their adsorption slopes differed by more than 1 order of magnitude. The particle-size effect on adsorption is constant over a pH range of 4-7.5. The desorption of Cd(2+) from both particle sizes is completely reversible. The adsorption data have been modeled by the Basic Stern model using three monodentate surface complexes. It is proposed that intraparticle electrostatic repulsion may reduce the adsorption free energy significantly for nanometer-sized particles.

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The effectiveness of multiwalled carbon nanotubes (MWCNTs) as strain sensors is investigated. The key contribution of this paper is the study of real-time strain response at the macroscale of MWCNT film under tensile load. In addition, real-time voltage change as a function of temperature is examined. MWCNT films attached to a brass specimen by epoxy using vacuum bonding have been studied. The brass specimen is subjected to tensile loading, and voltage output from the MWCNT film is obtained using a four-point probe and a sensitive voltage measurement device. Experimental results show that there is a linear change in voltage across the film when subjected to tension, and the MWCNT film both fully recovers its unstressed state upon unloading and exhibits stable electromechanical properties. The effect of temperature on the voltage output of the nanotube film under no load condition is investigated. From the results obtained it is evident that MWCNT films exhibit a stable and predictable voltage response as a function of temperature. An increase in temperature leads to an increase in conductivity of the nanotube film. The study of MWCNT film for real-time strain sensing at the macroscale is very promising, and the effect of temperature on MWCNT film (with no load) can be reliably predicted.