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Background: Rifampicin (RIF), also known as rifampin, a bactericidal antibiotic having broad antibacterial activity against various gram-positive and gram-negative bacteria act by inhibiting DNA dependent RNA polymerase. RIF has been administered in different dosage forms like tablets, capsules, injections, oral suspension, powder etc. for the treatment of several types of bacterial infections, including tuberculosis, Mycobacterium avium complex, leprosy and Legionnaires’ disease. Introduction: To ensure the quality, efficacy, safety and effectiveness of RIF drug product, effective and reliable analytical methods are utmost important. To quantify RIF for quality control or pharmacokinetic purposes, alternative analytical methods have been developed along with the official compendial methods. Method: In this review paper, an extensive literature survey was done to gather information on various analytical instrumental methods used so far for RIF. Result: These methods were high-performance liquid chromatography (42%), hyphenated techniques (18%), spectroscopy (15%), high-performance thin-layer chromatography or thin-layer chromatography (7%) and miscellaneous (18%). Conclusion: All these methods were selective and specific for the RIF analysis.

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To get chitosan beads, an ionotropic gelation technique was used in which drug containing chitosan solution added into tripolyphosphate solution. Obtained beads were evaluated to study the effect of Span 80 and methods of drying on their properties. Air drying method resulted in shrunken beads, the oven drying method resulted in dark, brittle and cracked beads, and freeze-drying method showed adverse effect on sphericity and surface topography of the beads. Higher proportion of Span 80 in the beads showed faster release. Oven-dried beads gave delayed release compared to air- and freezedried beads. In vitro drug release data depicted t70% at 365 min with 88.17 % drug release for 12 h. Thus, formation of controlled release beads can be inferred.