A series of novel Schiff' base-containing a 7-amino-4-methylcoumarin moiety have been synthesized III a-l, characterized by spectroscopic data and studied for their anti-inflammatory and analgesic activity. The results of the anti-inflammatory and analgesic activity evaluation of 7-(substituted benzylideneamino)-4-methyl-2H-chromen-2-one derivatives III a-l proved to be comparable or more potent with respect to the reference drugs. In particular, compounds 7-(4-chlorobenzylideneamino)-4-methyl-2H-chromen-2-one III f, 7-(2,4-dichlorobenzylideneamino)-4-methyl-2H-chromen-2-one III g and 7-(4-bromobenzylideneamino)-4-methyl-2H-chromen-2-one III h exhibited potent anti-inflammatory and analgesic activity.

Antiinflammatory activity X 0130 Synthesis of Novel Substituted 7-(Benzylideneamino)-4-methyl-2H-chromen--2-one Derivatives as Antiinflammatory and Analgesic Agents. -Among a series of title compounds the derivatives (I) exhibit potent antiinflammatory and analgesic activity. -(RONAD*, P.; DHARBAMALLA, S.; HUNSHAL, R.; MADDI, V.; Arch. Pharm. (Weinheim, Ger.) 341 (2008) 11, 696-700; Dep. Pharm. Chem., KLE Coll. Pharm., Karnataka 575 025, India; Eng.) -H. Haber