Oral thyroxin supplementation improves the CI and reduces the inotropic requirement. In addition, it reduces the duration of mechanical ventilation, ICU and hospital stay, and therapeutic intervention scoring system in infants after surgery for complex congenital heart defects.

Objective: Polymorphisms in vitamin D receptor (VDR) genes are known to be linked with different metabolic diseases including Type 2 diabetes mellitus (T2DM) also. However, the association of these polymorphisms is not much explored for the Indian population. To determine the prevalence of BsmI and TaqI polymorphism in VDR gene of T2DM patients from North India.Methods: Blood samples were obtained from 100 well-characterized T2DM patients and 100 healthy controls. Genomic DNA was isolated from blood samples and using polymerase chain reaction/restriction fragment length polymorphism based method, the presence of these polymorphisms was investigated in these samples. The data were statistically analyzed using SPSS 21.0 software. Results:For TaqI polymorphism, both the wild type (TT) and heterozygous (TC) genotype showed a significant difference between patients and controls (p=0.023 and p<0.001, respectively). Whereas, the frequency of CC genotype was not significantly different among these groups (p=0.506). For BsmI polymorphism also, the frequency of wild type (GG) and heterozygous (GA) genotype was significantly different in patients and controls (p=0.027 and p=0.001), respectively. However, the frequency of AA genotype was not of statistical significance in patients (p=0.071). Conclusions:The mutant alleles of TaqI and BsmI polymorphisms are known to be associated with different metabolic diseases, including diabetes too. In our study also, there is a significant difference between the frequency of wild type and heterozygous genotype for these polymorphisms. This suggests that BsmI and TaqI polymorphisms may be associated with T2DM patients.