Bleb needle revision with high-dose MMC was effective in reducing the IOP in 64% of eyes with a failed filtering bleb with minimal long-term complications.

(BrJ Ophthalmol 1996;80:1055-1059 The aetiology of the glaucomas remains obscure. Currently two hypotheses are most credible: a mechanical theory, which proposes that excessive pressure deformation of the optic nerve head triggers cell death,2 and a vascular theory, which argues that vascular insufficiency (or vasospasm) tion between flow velocities in two major retrobulbar vessels (the ophthalmic and central retinal arteries) and the IOP, we used scleral suction to vary IOP over a wide range in healthy eyes. We could then determine if blood velocities in these two vessels were dependent on ocular tension. Materials and methods SUBJECTSAll subjects had normal eye examinations, and no history of systemic or ocular hypertension. Measurements were made on the left eye; 11 volunteers were involved in studies of the ophthalmic artery, and nine other volunteers were included in investigations of the central retinal artery. Procedures were reviewed and approved by human subject protection committees at Indiana University and the University of Miami, and subjects signed informed consent before participating. All experimental procedures conformed to the tenets of the Declaration of Helsinki.

Although the power of this study was limited, our preliminary data suggest that disease susceptibility genes in MS in the Indian population may be similar to those of western populations.

Suboptimal reprocessing of cataract surgical equipment may evolve over time in busy, multidisciplinary surgical centers. Clinically significant contamination of surgical equipment may result from inappropriate maintenance of steam sterilization systems. Standardization of protocols for reprocessing of cataract surgical equipment may prevent outbreaks of TASS and may be of assistance during outbreak investigations.