Background: Trigeminal neuralgia (TN) is a chronic disorder, characterized by unbearable, sudden facial pain, often leads people to suicide. Thus TN is referred to as suicide disease. Aim: The ability of four formulations based on natural medicine, homeopathic, dietary supplements and ayurvedic herbs in different combinations to reduce the complications of TN was investigated with comparative evaluation. Materials & Methods: The study was performed through survey. Questionnaire related to demographic and illness information with TN patient's feedback on the formulations after use, was prepared and randomly sent to the patients, who have received the treatment at the clinic. The responses were collected electronically and detailed statistical analysis was carried out to evaluate the outcome of the treatment. Results: Combinations of all four Biogetica® formulations showed more potential in reducing the disease complications. The treatment with these formulations also displayed improvement in the patient's ability to perform physical activities. Furthermore, no side effects were observed for these formulations after treatment. The combination of 4 biogetica formulas improved the health rate of 68%TN patients. Such results have not been seen in any Drug treatment or gamma knife Surgery. Maximum number of patients ( 26) got the positive result in about 15 to 45 days. But, interestingly, 21 patients got their pain relieved within 15 days of time. Conclusion: The combination of natural medicine, homeopathic, dietary supplements and ayurvedic herbs are effective in alleviating the complications of TN without any adverse effects. Therefore, Biogetica® formulations can be used safely in the treatment of TN.