A metal-free visible-light-induced phosphonylation of 2H-indazoles with diphenylphosphine oxide has been developed using rose bengal as an organophotoredox catalyst under ambient air at room temperature. A library of diphenyl(2phenyl-2H-indazol-3-yl)phosphine oxide with broad functionalities has been synthesized in high yields. The experimental result suggests the radical pathway of the reaction.

An environment-friendly method for the chlorination of imidazoheterocycles has been developed using chloramine-T, a novel chlorinating reagent. A bunch of C-3 chloro-substituted imidazo[1,2- a ]pyridines with variety of functionalities have been synthesized in good yields under neat condition at room temperature within very short time. This chlorination process is also applicable to imidazo[2,1- b ]thiazole scaffolds. The present methodology is relevant to gram-scale synthesis. The major advantages of this system such as wide applicability, easy availability of reactants, open-air and metal- and solvent-free reaction conditions, no need of work-up, and simple purification technique represent a green synthetic protocol.

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Solvent interaction has a significant effect on the molecular motions, folding and self-assembly of short aromatic γ-peptides that leads to a change in initial helical conformation.