Background: To analyze the clinical findings and haematological profile of multiple myeloma patients. Material and methods:All newly diagnosed patients of multiple myeloma between January' 2013 to December' 2015 in the department of pathology, Indira Gandhi Medical College, Shimla were the study subjects. The history and clinical findings were recorded. All relevant blood, radiological investigations including peripheral smears, bone marrow aspiration and biopsy were done.Results: Fifty one patients were diagnosed with multiple myeloma and they comprised 19% of all haematological malignancies. Out of these, 30 were males and 21 females with a mean age of presentation 58.38 years. The commonest presenting complaint was bone pain followed by fever, CKD and bleeding disorder. Common clinical findings were anemia, osteolytic lesions and renal insufficiency. M band was seen in 83% of patients on serum protein electrophoresis. On bone marrow examination, majority (53%) of patients had plasmablastic morphology while, 47% had plasmacytic features. Diffuse pattern of infiltration on bone marrow biopsy was observed most commonly in 68.3%patients. Conclusion:The present study concluded that multiple myeloma is a disease of middle age and elderly with male preponderance. The clinical presentation varies with bone pain being the most common presenting complaint. Morphologically,plasmablastic morphology predominated on bone marrow aspiration while diffuse pattern of infiltration was observed on bone marrow biopsy.