Introduction: The role of inflammation and malnutrition in critically ill patients has been shown in some studies. The aim of the study is to determine the effect of symbiotic on serum systemic inflammatory marker (hs-CRP) and albumin in critically ill patients.Methods: Sixty patients admitted to the intensive care unit of Sabzevar Vasei hospital were randomized two groups that received symbiotic or placebo for 2 weeks. Levels of serum hs-CRP and albumin were measured before and after the study. Results:There was a significant differences between two groups the Levels of serum hs-CRP (P=0.0001) and albumin (P=0.0001). Conclusion:Results of study were showed that administration of symbiotic in critically ill patients reduced the levels of serum hs-CRP and increased the levels of serum albumin.