We report a case of a 38-year-old woman who was initially misdiagnosed with hepatic tuberculosis and was managed as such before being correctly diagnosed with hepatosplenic schistosomiasis on liver biopsy. The patient had a five-year history of jaundice which over time was accompanied by polyarthritis and then abdominal pain. A diagnosis of hepatic tuberculosis was made clinically and supported by radiographic evidence. She underwent an open cholecystectomy for gallbladder hydrops with the liver biopsy taken revealing chronic hepatic schistosomiasis and was eventually started on praziquantel with good recovery. This case demonstrates a diagnostic issue with the radiographic presentation of the patient and the important role of tissue biopsy in providing definitive care.