M icroemulsions serve as ideal candidates as potential drug delivery system due to their specialized qualities of improved solubilisation of drug, extended shelf life and ease of method of preparation and administration to patients. The unique features of microemulsions are thermodynamically stable, clear, colloidal dispersion of water and oil that are stabilized by surfactant and cosurfactant. Microemulsion typically has a droplet diameter of approximately 100 nm or less. Microemulsions have numerous applications in pharmaceutics and many other industries. In the present review we shall discuss about the various aspects of microemulsion with respect to the field of non steroidal anti inflammatory drug, along with its preparation, evaluation and research work carried out in microemulsion.

The use of medicinal plants in modern medicine suffers from the fact that though hundred of plants are used in the world to prevent or to cure disease, scientific evidence in term of modern medicine is lacking in most cases. However, today it is necessary to provide scientific proof as to whether or not it is justified to use a plant or its active constituents. Pain and inflammation are considered one of the oldest known diseases of mankind and affects a large population of the world, unsatisfactory progress and lack of proper scientific evidences has enriched this disease worldwide. Diplazium esculentum is one of the most popular fern which is also used for medicinal purposes. Various parts of the D. esculentum are used for numerous purposes. However, its analgesic activity is still a mystery for the scientific world. So this study includes successive extraction and pharmacological evaluation of the analgesic activity of various extracts obtained from D. esculentum. To investigate the analgesic activity, 'acetic acid induced writhing' method in mice was used. The various extracts obtained were subjected to analgesic activity. The finding of this study highlighted several novels and important aspects of the extracts derived from D. Esculentum.

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