Siddha system of medicine is one of the oldest systems of medicine practised among Tamil speaking community. The medicines in this system are prepared from raw materials like herbs, minerals/metals and animal products. Kandhaga Rasayanam is a herbo mineral formulation with 16 ingredients. It is used for treating skin diseases, arthritis, leucorrhoea, urinary diseases etc. This review is aimed to bring out scientific evidence for the therapeutic usage of Kandhaga Rasayanam and focussed on the pharmacological activity responsible for the curative nature of the drug. Most of its drugs have antimicrobial, anti-inflammatory activity hence justifying its usage in above mentioned diseases.
Tinea infection of skin is analogous with Padarthamarai kuttam in Siddha system of medicine, which is one among the AYUSH systems of medicine. The conventional treatment available is topical antifungal creams and oral antifungal drugs. The Siddha medicine being safe and cost effective was used to treat a patient diagnosed as Padarthamarai. A 47 year old male was treated with Kandhaga Rasayanam, a Siddha herbo-mineral formulation having Sulphur as the sole mineral ingredient. The response was very good in terms of itching and erythema. The newly appeared lesions of Tinea corporis vanished and the hyperpigmentation in two lesions remained as such. The skin scrapings were negative after treatment. The response was good and there was no relapse in the follow up period. Since there was no external medicines prescribed, a treatment package with an external drug with larger number of population in a controlled environment will help in further validating the treatment.
Mimosa pudica is a traditional Siddha medicinal plant useful in the treatment of various neurological (vaatham) disorders. The main objective of the study is to demonstrate the neuroprotective effects of Mimosa pudica on against MPTP induced Parkinsonism in mice model. Male C57BL/6J mice (20-25 g bwt) were used for the study. Following acclimatisation the animals were divided into five groups with 6 in each. Group served as I negative control, Group II served as MPTP group, Group III as carbidopa 250 mg/kg IV & V as Mimosa pudica at 100 and 300 mg/kg, respectively. Animals were pretreated with vehicle or drugs (once a day) for five consecutive days. On day 5, one hour after vehicle or drug administration, MPTP was injected intraperitoneally at 80 mg/kg b.wt in two divided doses (2 X 40 mg/kg bwt. at 16 h interval). Forty eight hour after MPTP, animals were assessed for motor functions using horizontal grid test and vertical grid test. Then the animals were euthanised and brains were collected and processed for immunohistochemical analysis of dopamine transporter (DAT), tyrosine hydroxyalse (TH) and α-synuclein (α-syn) expressions. Mimosa pudica improved DAT and TH expressions.α-syn expression was significantly decreased in mimosa treated animals when compared to vehicle treated animals. The results indicate mimosa pudica is a potent neuro-protective agent against MPTP induced Parkinsonism.
<p>Due to erratic climate change, vector-borne diseases started flaring up from the second half of the last decade. Siddha medicine has been used as a public health tool to effectively manage chikungunya and dengue in the epidemics that happened in 2008 and 2016. Tamil Nadu government has made enormous efforts to control vector-borne diseases. Due to which morbidity and mortality due to vector borne diseases came down compared with other states. Two official Siddha formulations, namely Kabasura Kudineer Chooranam and Nilavembu Kudineer Chooranam and novel herbal formulation – JACOM, are used to combat vector-borne diseases. These decoctions lack an evidence base as a formulation. Screening has been done to check the efficacy of the formulation in inhibiting neuraminidase. Neuraminidase inhibition assay was performed to determine the activity of Siddha formulations. The Kabasura Kudineer Chooranam, Nilavembu Kudineer Chooranam and JACOM showed excellent inhibitory activity. The Kabasura Kudineer and Nilavembu Kudineer and JACOM aqueous extract showed maximum neuraminidase inhibition of 80.35%, 91.78% and 87.97%, respectively.</p>
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